Effects of ultrafine diesel exhaust particles on oxidative stress generation and dopamine metabolism in PC-12 cells
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چکیده
منابع مشابه
Ultrafine Particles of Diesel Exhaust Induces Cytochrome P450 1A1 Mediated Oxidative Stress and DNA Damage in Cultured Blood and Lung Cells
Attempts were made to investigate the role of cytochrome P450 1A1 (CYP1A1) on similarities in the generation of reactive oxygen species (ROS) and DNA damage in IM9, a human B lymphoblastic cell line with A549, the human lung adenocarcinoma epithelial cell line on exposure of diesel exhaust particles (DEP). A suspension of ultrafine particles (< 0.2 μM) of DEP (1mg/ml) in DMEM-F12 medium, at a c...
متن کاملGenotoxicity, and Oxidative Stress in Pc-12 Cells
Previous studies have indicated that heavy metal exposure can have an effect on the central nervous system. However, research has been inadequate to fully support this claim. The aim of this work was to determine the toxic effects of heavy metal ions including Fe, Fe, Hg, Mn, Cd, Mg, and Pb on nerve cells (e.g. PC12). PC12 cells were incubated with the metal ions at four concentrations, i.e. 12...
متن کاملExposure to diesel exhaust fumes in the context of exposure to ultrafine particles.
OBJECTIVES Diesel exhaust fumes emission is a significant source of ultrafine particles, the size of which is expressed in nanometers. People occupationally exposed to diesel exhaust particles include mainly workers servicing vehicles with engines of this type. This article presents the analysis of measurements of ultrafine particle concentrations occurring in the bus depot premises during the ...
متن کاملInflammation-Related Effects of Diesel Engine Exhaust Particles: Studies on Lung Cells In Vitro
Diesel exhaust and its particles (DEP) have been under scrutiny for health effects in humans. In the development of these effects inflammation is regarded as a key process. Overall, in vitro studies report similar DEP-induced changes in markers of inflammation, including cytokines and chemokines, as studies in vivo. In vitro studies suggest that soluble extracts of DEP have the greatest impact ...
متن کاملExperimental Study on Diesel Exhaust Particles Agglomeration Using Acoustic Waves
Diesel exhaust particles are a complex mixture of thousands of gases and fine substances that contain more than 40 different environmental contaminants. Being exposed to these exhaust particles (called soot) can cause lung damage and respiratory problems. Diesel particulate filters are used in many countries for mobile sources as a legal obligation to decrease harmful effect of these fine pa...
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ژورنال
عنوان ژورنال: Environmental Toxicology and Pharmacology
سال: 2014
ISSN: 1382-6689
DOI: 10.1016/j.etap.2014.03.008